AC repair inMidway, GA

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As a homeowner, you know that your HVAC unit is one of the most important components in your house. It keeps you cool during hot summer days and warm on chilly winter nights. When it's working properly, it's easy to forget its important role in your everyday life. But when it malfunctions, you quickly remember how crucial heating and AC repair in Midway, GA, is for your family.

At Liberty Heating & Airworx AC, our mission is to ensure your cooling and heating systems remain effective throughout the year at the lowest prices available. Unlike some of our competitors, we prefer to put our customers first before anything else. We believe in doing right by the folks who choose our business. Cutting corners to save a few bucks? Annoying sales pitches to try and sell you new parts or equipment? That's just not the way we do business.

When you choose Liberty Heating & Airworx AC, you can rest easy knowing you won't have to pay outlandish fees for our services. As a licensed, bonded heating and air conditioning company, we know how important trust is when it comes to the nature of our business. We go above and beyond other HVAC companies and treat your home like it was our own. That way, you have peace of mind knowing you and your family are in capable, responsible hands.

We take pride in providing our customers with the highest quality service. Our highly trained technicians have experience handling all aspects of HVAC repair, from routine maintenance problems to advanced A/C unit installation projects in Midway, GA.

Through hard work, honesty, and integrity, we have built a loyal customer base that continues to grow each month. It would be our honor to call you our customer too. Whether you need a routine maintenance check or emergency heater repair in Midway, we are here for you every step of the way, 24-hours a day.

Air Conditioning Repair Services Midway, GA

Service Areas

Why Choose Liberty Heating & Airworx AC?

We get it - there are a lot of A/C companies out there to sift through. You want to be sure you choose the best company for your needs and budget.

 AC Repair Services Midway, GA

Here are just a few reasons why our customers choose Liberty Heating & Airworx AC over other HVAC companies in South Georgia:

Authorized Carrier and Goodman Dealer:

Authorized Carrier and Goodman Dealer:

We're authorized to service and sell two of the most respected brands in the heating and A/C industry. No matter what size home you own, our technicians are fully equipped to handle any HVAC issue with your Goodman, Carrier, or other air conditioning units.

Insured, Bonded, and Licensed:

Insured, Bonded, and Licensed:

We go the extra mile to ensure that our customers feel safe and protected when they hire our team. We treat your home like it was our own, from the moment we step foot on your property to the time we pull out of your driveway.

Fair Pricing

Fair Pricing

We understand that money doesn't just grow on trees. You work hard to make an honest living and need reasonable pricing on A/C repair and other HVAC services. At Liberty Heating & Airworx AC, you'll never have to worry about us charging you outrageous prices.

Flexible Financing

Flexible Financing

Has your heater gone out in the middle of a freezing January night? A/C unit quit working in the middle of summer? Despite some common red flags that you can keep an eye out for, you can never really plan for an HVAC malfunction. That's why we offer emergency HVAC services in Midway, 24-hours a day, seven days a week.

Year-Round Discounts

Year-Round Discounts

With Ft. Stewart just a few minutes away, Midway has one of Georgia's largest active military populations. It is our honor to offer current and retired military members and their families discounted prices on their next service appointment. We also offer up to 10% off for Federal Law Enforcement Training Center Members. It's our small way of giving back to those who have sacrificed so much for our liberty.

Free Estimates

Free Estimates

From new unit installations to air conditioning repair, it would be our pleasure to provide you with a free estimate on our services.

Emergency Service

Emergency Service

Has your heater gone out in the middle of a freezing January night? A/C unit quit working in the middle of summer? Despite some common red flags that you can keep an eye out for, you can never really plan for an HVAC malfunction. That's why we offer emergency HVAC services in Midway, 24-hours a day, seven days a week.

Flexible Financing

Flexible Financing:

When your A/C unit or heater breaks suddenly, it can be hard to squeeze repairs into your budget. To make sure all of our customers are comfortable in their homes, we offer financing options to make your life easier.

Air Conditioning Repair in Midway, GA

Here in southern Georgia, our summers can be extremely hot and humid. Trying to live in a home without A/C a South Georgia summer isn't just a bad idea; it can be downright deadly. Fortunately, Liberty Heating & Airworx AC is here to help with all of your A/C needs. There's no A/C issue that our highly trained HVAC technicians haven't seen before, and no job too small or large for us to tackle. Whether your A/C system needs a basic issue resolved, or you need a new AC unit installed at your house, our team will be at your door in no time.

We have the experience and training to service all major air conditioning systems, from ductless systems to central air setups. We're authorized to service Goodman to Carrier brands, but the truth is it doesn't matter what A/C unit brand you have - our team can fix it all. If your unit is beyond repair, we can walk you through the process of installing a new A/C system and suggest appropriate units that will work well for your home.

Here are just a few of the most common A/C repair services we offer in Midway and the surrounding area:

  • Electrical repair
  • Compressor Repair
  • Refrigerant Leaks
  • Refrigerant Recharges
  • Replace Blower Motor
 AC Repair Midway, GA

Common Signs That
You Need AC Repair in
Midway, GA

Once springtime rolls around, it's very important that you keep your eyes and ears open for any potential warning signs that your A/C unit needs to be repaired. The last thing you need is to be caught off guard when June, July, and August are in full swing. Knowledge is power, and at Liberty Heating & Airworx AC, committed to keeping our customers in the loop about potential A/C repair warning signs. That way, you can take preventative steps rather than reactive ones.

 Heater Repair Services Midway, GA
Loud-Unusual-Noises
Loud, Unusual Noises

Don't be alarmed if your A/C unit makes low-level noises throughout the day and night - these sounds are completely normal. However, if you hear loud, unusually abrupt noises coming from your unit, it may be time to have it repaired. Buzzing or rattling noises can mean a part is loose, while grinding or whistling can signal a more serious problem. Because these types of issues won't work themselves out on their own, a professional is needed to diagnose and correct the problem.

Strong-Odors
Strong Odors

If you notice strange, smelly odors permeating throughout your home, your first instinct may be to grab the air freshener. However, unpleasant odors can be a sign that your A/C unit needs attention. Our A/C repair techs will let you know what's going on and how a potential issue can be remediated with a quick diagnostic test.

Refrigerant or Water Leaks
Refrigerant or Water Leaks

Your A/C unit needs refrigerant to keep your home cool and comfortable when it's hot outside. It's common for condensation to accumulate as your system cools your home. With that said, if you notice pooling water or an active leak coming from your A/C system, it's time to call an A/C repair tech ASAP. Leaks can cause extensive damage to your home, and the problem needs to be addressed quickly.

Heater Repair in
Midway, GA

South Georgia isn't known for its freezing temperatures, but one thing is for sure - wintertime in Midway can get very cold. When the temps begin to drop, your home's furnace works properly. Modern homes have come a long way since the days of wood and coal. Your home's heater is complicated, and when one component fails, the entire system can be affected. In situations like these, it's important not to panic. Instead, give Liberty Heating & Airworx AC a call. Our trustworthy team of heating repair experts have the knowledge and training to repair your furnace fast, so you can get back to enjoying your home.

Here are just a few of the most common issues that we can help repair:

  • No Heat
  • Thermostat Malfunction
  • Heat Pump Replacement
  • Ignition and Pilot Problems
  • Noisy Heater
  • Emergency Services
  • Much More!
 Heating And AC Services Midway, GA

Common Signs That You Need Furnace Repair in Midway, GA

 Heating And Cooling Repair Midway, GA

Today's heating systems are complex. At Liberty Heating & Airworx AC, our heating repair technicians receive ongoing training in all aspects of heating technology. That way, their skills stay sharp, and their techniques remain up to date. However, you don't need to be an expert to spot common signs that your heater may need to be repaired.

As colder months approach in Georgia, try to be aware of the following red flags:

Expensive Heating Bill

You're probably used to a more expensive electricity bill when winter hits Midway. However, if you notice a huge price jump over last year's bill, it could be a sign that something is wrong with your heating system. Utility companies are known for raising prices gradually, but a dramatic leap is a cause for concern.

Uneven Heating
Uneven-Heating

Does your heater seem to work perfectly in some areas of your house but not others? Are some rooms too hot while others are drafty and cold? If so, your heater may need repairing. This is a common issue in older homes and requires an expert to inspect your heater and ducts for airflow problems.

Unhealthy Air Quality
Unhealthy Air Quality

If the air in your house is hazy no matter how much you dust, your heater may be the problem. A furnace that circulates mildew, dust, and other harmful particles isn't working correctly. This issue is particularly bad for people with asthma or respiratory illnesses. If you haven't changed your home's air filter recently, be sure to do so. If the problem persists, it's time to call Liberty Heating & Airworx AC.

New AC Installation
in Midway, GA

You and your family depend on your home's A/C system to keep you cool and comfortable during the hottest months of the year. Unfortunately, breakdowns happen at the worst possible times - like in the middle of July when temperatures are over 90 degrees. If you have had to repair your A/C system more and more often, investing in a new cooling system will save you time and money in the long run.

As an Authorized Carrier and Goodman dealer - two of the most recognized and respected brands in our industry - we have the highest quality units available. We handle every aspect of your new A/C installation from start to finish. That way, you can focus on living your life rather than worrying about the next time your A/C goes out.

Curious when it might be time for a new A/C system?

Keep an eye out for these warning signs:

Dusty Furniture

 HVAC Midway, GA

If you have kept your unit well-maintained and changed your air filter regularly, you shouldn't experience this problem. If you do, and your system is old, it can be more cost-effective to replace it and have your duct system analyzed to fix the root cause of your dust issue.

High Humidity

 HVAC Repair Services Midway, GA

If it feels unusually sticky in your home, like you just spent a few hours outside in the summertime, there's a good chance that something is seriously wrong with your air conditioning. Your air conditioner's job is to pull moisture out of the air to keep your feeling cool inside. When that process fails, it can increase your risk of mold and mildew growth - and that's just the start.

Frequent Repairs

 HVAC Services Midway, GA

When your repair bills end up costing more than a down payment on a new A/C system, it might make more financial sense to invest in a more modern unit. Compare how much it costs to have our maintenance technicians perform regular service vs. the cost of a new air conditioning installation. The results may surprise you.

Liberty Heating & Airworx AC

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Latest News in Midway, GA

4 Affordable Waterfront Airbnbs In Georgia You Can Escape To This Fall

Narcity may receive a small commission if you buy something from this article, which was created independently by Narcity's editorial team just for you.If you ever dream of waking up to the view of the ocean, lake, or even the river, you're probably not alone. There's nothing like the feeling of drinking a morning coffee on the porch while listening to the water trickle by for a sense of tranquillity.While some are lucky to have this every day, there are a few ...

Narcity may receive a small commission if you buy something from this article, which was created independently by Narcity's editorial team just for you.

If you ever dream of waking up to the view of the ocean, lake, or even the river, you're probably not alone. There's nothing like the feeling of drinking a morning coffee on the porch while listening to the water trickle by for a sense of tranquillity.

While some are lucky to have this every day, there are a few waterfront Airbnb rentals in Georgia that'll give those who don't a little taste of that dream.

The Peach State has numerous rivers and lakes and even a full coast of beaches, so your waterfront rental options are endless. They make for perfect romantic getaway weekends, or even a BFF trip to have some fun and leave reality behind for a few days.

These four spots won't cost an arm and a leg either, even if they look like they would at first glance. When you split costs among a group of friends, you'll save some major cash.

River Front Getaway

Price: $219 per night

Location:Midway, GA

Why You Need To Go: This secluded riverfront home has both a pool and a dock leading out to the river. The sunsets are one-of-a-kind here and you can even bring your boat to tie up if you have one. You can also sleep four people at this property.

Creek front cabin McCaysville, GA Near Blue Ridge

Creek front cabin McCaysville, GA Near Blue Ridge.

Price: $135+ per night

Location:McCaysville, GA

Why You Need To Go: This mountain cabin sits right in front of a creek which is perfect for those who like to trout fish or float on a tube. The backyard has a fire pit and chairs so you and up to six friends can sit and listen to the creek run for a sense of tranquillity.

Tranquil Marsh Setting Minutes to Savannah & Tybee

Tranquil Marsh Setting Minutes to Savannah & Tybee.

Price: $150 per night

Location: Savannah, GA

Why You Need To Go: This home sits right on a private marsh between Savannah and Tybee Island. You and your plus one can sit on one of the numerous decks and sip your coffee with incredible views.

Salt Water Escape - as the tides turn

Salt Water Escape - as the tides turn.

Price: $152+ per night

Location: Tybee Island, GA

Why You Need To Go: This cute house has a tidal pond in its backyard that's perfect to put in a kayak or a tube and just float away for the day. It sleeps four guests so it's perfect for a BFF group getaway.

These prices and terms of occupancy are confirmed at the time of publishing, but they can change at any time. Taxes and fees may not be included in the price.

Before you get going, check our Responsible Travel Guide so you can be informed, be safe, be smart, and most of all, be respectful on your adventure.

This article has been updated since it was originally published on July 29, 2020.

It’s 2022. Time for Kings and Barons 4.0.

This whole thing started with the Georgia Bulldogs.In an offseason mailbag 15 years ago, I innocuously referred to Georgia as a “regional power.” This was midway through Mark Richt’s tenure, a decade before Kirby Smart would come in and turn the program into a behemoth. Still, many Bul...

This whole thing started with the Georgia Bulldogs.

In an offseason mailbag 15 years ago, I innocuously referred to Georgia as a “regional power.” This was midway through Mark Richt’s tenure, a decade before Kirby Smart would come in and turn the program into a behemoth. Still, many Bulldogs fans took this as a slight at the time.

The next week, Adam from Philadelphia — a Penn State fan — asked me: “Can you give us rankings of schools and their prestige and place in the national scene?”

So I decided to divide all power conference teams into a four-tiered feudal hierarchy: Kings, Barons, Knights and Peasants. For reasons I don’t understand but immensely appreciate, loyal readers reference my entirely subjective rankings to this day. The list is only partially tied to actual on-field performance. It’s more a measuring stick of which programs’ brands carry the most national cachet.

And because brands tend to be pretty resilient, I’ve held firm about only updating the list once every five years — previously in 2012 and 2017.

It’s 2022. Time for Kings and Barons 4.0.

And of course, that means coming full circle on Georgia.

The Dawgs were not among my original list of 13 Kings. “Suppose we went to, say, Montana,” I wrote at the time. “And suppose we found 100 ‘average’ college football fans … if I held up a Georgia “G” helmet, how many of them do you think would be able to identify it off the top of their head?”

A Georgia blogger known as Senator Blutarsky never forgot that line. Five years later, when Georgia remained a Baron, he found a volunteer to literally go to sports bars in Montana with a video camera and a Georgia helmet asking folks if they could identify it. (Final tally of the “Montana Project:” 73 yes, 27 no.)

Well, how’s this for serendipity? My next re-rank would always be in 2022. So, of course, Smart, who already had elevated Georgia’s profile substantially in the past five years, went and led the Dawgs to their elusive first national championship since 1980 just five months before this would run, ensuring their deserved step up to the ruling class.

Reached for comment, Senator Blutarsky — also known as Michael Brochstein of Atlanta — responded humorously (I think), “Bout damn time.”

College football has changed immeasurably since August 2007. Nick Saban had yet to coach his first game at Alabama; the now-defunct Big East was still considered one of six power conferences; and we were seven years away from the demise of the BCS.

One undeniable consequence of the now eight-year-old College Football Playoff is the consolidation of power among a small handful of programs. With only a few exceptions, a program’s national profile these days seems to go hand in hand with regular CFP contention.

Therefore, this year’s edition sees the Kings undergo their most significant contraction to date. But! I felt the need to create a new category above that one. Teams that have moved up since 2017 and teams that moved down are noted below the tables.

I thought about elevating Alabama, Ohio State, Clemson and Georgia into their own ruling class to reflect their recent dominance. But then I realized that didn’t do justice to a program that, since its initial classification as a King in 2007, has won six national championships and played for three more. The Tide now own 13 poll-era national titles, five more than next-closest Notre Dame. They are truly in a class unto themselves.

Who’s a new king: GeorgiaWho lost their kingdoms: Florida, Florida State, Miami, Penn State

All but two of these programs have reached the Playoff. Ohio State is the one brand that consistently draws Alabama-esque TV ratings, but Michigan and Notre Dame aren’t far behind. Clemson’s national perception still suffers from a bit of guilt by ACC association, but it’s hard to deny Dabo Swinney has turned the Tigers’ program into a national power. LSU has won three national titles since 2003, and Oklahoma has reached seven BCS title games or CFP semifinals since 2000.

Some will roll their eyes at Texas’ continued inclusion, but if you have the power to orchestrate your own move into a better conference and send the entire sport into chaos, you are in fact a King. Some will roll their eyes at USC’s continued inclusion, but if you can steal away another King’s highly successful head coach, you, too, are a King.

Who’s a new baron: Iowa Who lost their fiefdoms: Stanford, UCLA, Virginia Tech

It’s all about exclusivity, as we now have just two Kings or Barons that have moved up a rung since 2017 (Georgia, Iowa) but seven (Florida, FSU, Miami, PSU, Stanford, UCLA, VT) I’ve moved down a tier.

As a child of the 1980s and early 1990s, it’s surreal to see all three Florida powers now relegated to second-tier status. But I’m arguably five years behind on Miami. Florida was on top of the sport as recently as 2008, but Alabama, LSU and Georgia have long since stolen the Gators’ SEC thunder. And Florida State, less than a decade removed from its most recent national championship, has sullied its brand immensely in recent years. TV viewers don’t even tune in to see the train wreck the way they do Texas or USC.

Reclassifying Penn State was a much tougher call, as the Nittany Lions have a strong national fan base and always draw eyes for those White Out games. But that run of three 11-win seasons in four years from 2016-19 was an aberration for a program that has finished in the Top 25 just four times in 12 years. There was a brief moment when James Franklin had Penn State going toe-to-toe with Ohio State, but that moment has passed. I get the sense Penn State’s national profile is closer to those of Michigan State’s and Iowa’s than Ohio State’s or Michigan’s.

I try very hard to avoid recency bias in these things, but Stanford as a Baron was entirely a product of the Cardinal’s great run from 2010-15, whereas I held off for a decade before conceding UCLA and Virginia Tech aren’t what they once were.

While unintentional, 15 of the 22 Emperors, Kings and Barons are from the Big Ten or SEC or Notre Dame. I believe that accurately reflects the increasing consolidation of power among those two conferences, which together accounted for 10 of the 12 most-watched games during both the 2019 and 2021 regular seasons.

Who’s a new knight: Kentucky, Minnesota, Mississippi State Who lost their knighthood: Colorado, Illinois, Maryland, Syracuse, Virginia

A strong case could be made that Baylor (four New Year’s Six bowls since 2013) and Oklahoma State (six Top 25 finishes since 2013) should be moved up to Barons by now. But I’ve seen the TV ratings, and for all their success, people just don’t watch those teams’ games to nearly the degree as Barons with longstanding brands, like Florida, Nebraska or Tennessee. Much the same with reigning Pac-12 champion Utah.

Conference affiliation plays an increasingly outsized role. Minnesota and Kentucky, while consistent bowl teams, have not had the same peaks as Baylor and Oklahoma State, but they get a lot of eyeballs by playing in the Big Ten and SEC. And do you realize Mississippi State has been to 12 consecutive bowl games? I didn’t, but once I did, it was hard to justify keeping the Bulldogs among the peasants.

I’m having trouble remembering why I haven’t demoted Colorado, Illinois and Syracuse sooner (although the Buffs were coming off a surprise Pac-12 South title in 2017). Virginia hasn’t been nationally relevant since the early 1990s, and Maryland is the rare program whose perception actually has been hurt by the Big Ten, in part because it’s now forever attached to the hip of Rutgers.

If I had to guess, the fan base I’m going to hear the most complaints from is Iowa State. Which, again: Beware recency bias. The past five years represent the best run in program history, but I’m not sure it’s completely erased a century of futility from the public consciousness.

Finally, I got a few requests to go ahead and include soon-to-be Big 12 members Cincinnati, Houston and UCF. (I already had BYU because the Cougars have long been a de facto Power 5 program.) I opted not to because, as of today, I’d default to all three Group of 5 schools as peasants, even after the Bearcats’ Playoff run. I’d rather wait and see how much they do or do not raise their profiles upon joining the Big 12 in 2023.

But hey, we’re already guaranteed to have changes to the hierarchy in version 5.0. See you in 2027.

Got questions, comments, complaints about my list? I’ll address them in Wednesday’s Mandel’s Mailbag.

(Illustration: John Bradford / The Athletic; Photos: Ronald Martinez, Michael Allio / Icon Sportswire via Getty; Matthew Stockman / USA Today)

First look inside Dave & Buster’s Augusta location

AUGUSTA, Ga. (WJBF) – Augusta is a fun and exciting place to live, and a new business in the area is making it even more fun and exciting.NewsChannel 6 was given a sneak peek at what you can expect inside.I’m here with General Manager George Dey to give us the rundown about what people can expect from the brand new Dave and Busters here in Augusta.“Dave and Busters, we’re all about fun. You want to come in and eat, drink, play, watch… whatever you ...

AUGUSTA, Ga. (WJBF) – Augusta is a fun and exciting place to live, and a new business in the area is making it even more fun and exciting.

NewsChannel 6 was given a sneak peek at what you can expect inside.

I’m here with General Manager George Dey to give us the rundown about what people can expect from the brand new Dave and Busters here in Augusta.

“Dave and Busters, we’re all about fun. You want to come in and eat, drink, play, watch… whatever you want to do. If you want to look at traditional, classic games. You want to look at our ‘Wow Wall’; that’s forty feet. Or, if you want to have something great from the kitchen or anything from our bar.”

For people who don’t know about Dave and Busters, give us a little rundown about what it is.

“Dave and Busters, we’re known for our midways. It’s called the ‘Million Dollar Midway’ for a reason. You have anything from virtual reality games. If you want to play anything from Pac-Man, state-of-the-art attractions, anything from retro games, as well. If you just want to shoot hoops all day or if you want to play Star Trek and win tickets you can go buy anywhere from candy to a PS5. Everything is out there for you.

We spoke with kitchen manager, Eric Jay, about what to expect on the menu.

If I’m coming here to Dave and Busters, in your opinion, what’s the one thing I have to try on the menu?

“One thing you’ve got to go with are the ribs. Our ribs are braised for three hours and we put a lot of heart into our ribs. You’ve got to go for the ribs.”

Is Dave and Busters the type of place you can bring your kids to?

“Most definitely,” says Dey. “Kids of all ages, everybody likes games. We’re here to have fun, and I think that’s what we’re going to do for Augusta.”

George, you guys have got some new games here at this location. Tell me a little bit about that.

“Absolutely. Every summer we pull out new games… as you look, we’re right next to dodgeball. Some very fun games I’m really excited for the community to come start playing.”

If you are a fan of games, fun, and excitement, you’ve got to come out and try the brand new addition to Augusta, Dave and Busters.

General manager George Dey wanted to show off some of his skills at Mario Kart and we were happy to play.

Dey also got a chance to sit down and give us a look at some of the items that can be found on the Dave and Busters menu.

Dave and Busters opens Monday, June 27th at 11 A.M. and is located on 925 Alexander Dr, Augusta, GA 30909.

Apellis: Mixed Data, But Definitely Approvable In GA

Apellis (NASDAQ:APLS) is the leader in developing therapies targeting the complement system. They have one approved product, one with an NDA that was recently submitted, two phase 3 trials and multiple earlier stage assets and target indications. Here’s how their pipeline looks:Lead candidate pegcetacoplan is approved for Paroxysmal nocturnal hemoglobinuria (PNH) in the US. ...

Apellis (NASDAQ:APLS) is the leader in developing therapies targeting the complement system. They have one approved product, one with an NDA that was recently submitted, two phase 3 trials and multiple earlier stage assets and target indications. Here’s how their pipeline looks:

Lead candidate pegcetacoplan is approved for Paroxysmal nocturnal hemoglobinuria (PNH) in the US. It was approved in May 2021, branded as EMPAVELI in the US and Aspaveli in EU. It is approved for use in adults with PNH who are:

In the registrational phase 3 PEGASUS study, EMPAVELI was found to be superior to Soliris in terms of change from baseline in hemoglobin level at Week 16. Moreover, 85% of patients on EMPAVELI were transfusion-free compared to only 15% on Soliris at week 16. The two drugs were comparable in transfusion avoidance.

The company also just submitted an NDA for pegcetacoplan in Geographic Atrophy or GA. The NDA was submitted on June 1, so there’s going to be a 2-month review period, and then a date will be provided. Given pegcetacoplan has a fast track designation in GA, expect the PDUFA in 6 months, or sometime in January 2023. GA is a leading cause of blindness in over five million people globally, and one million Americans. According to company management, “Pegcetacoplan is the only treatment that has shown the potential to meaningfully slow disease progression across three large studies with a representative, real-world population of GA patients.”

The company further says:

The NDA submission is based on results from the Phase 3 DERBY and OAKS studies at 12 and 18 months and the Phase 2 FILLY study at 12 months. In the studies, treatment with both monthly and every-other-month pegcetacoplan resulted in a clinically meaningful reduction of GA lesion growth across a broad, heterogenous population of more than 1,500 patients. Pegcetacoplan demonstrated a favorable safety profile in all three studies.

However, these statements are deceptive. The trials were mixed at best. When the company says there was “clinically meaningful” reduction of GA lesion growth, that’s code for it was not statistically significant - which it was not in the monthly dosage in the DERBY trial, and for DERBY and FILLY trials in the every-other-monthly dosage. In these 3 instances, the molecule failed to show statistical significance against placebo.

Also note that in a presentation last year, the company cited the following:

“Anything over 20% [reduction in lesion growth rate] would be significant in my mind.” – Retina Specialist

It is, therefore, interesting that none of the 6 data points showed a 20% reduction in lesion growth; the highest they achieved was 18%. Before Apellis, Roche (OTCQX:RHHBY) and Gemini (GMTX) failed to get a grip on geographic atrophy using the complement-mediated angle.

Even safety data wasn’t all that benign - there were instances of choroidal neovascularisations, which at 18 months increased to 9% and 6% of patients on the monthly and every-other-month dose respectively. Choroidal neovascularisations are a major cause of vision loss, which can, however, be treated with anti-VEGF therapy, while GA has no approved treatment. Other than that, safety data was decent, with no unexpected surprises.

I should note that after this data was first released, the stock dropped 50% despite efforts at putting a positive spin on the data from both the company and some analysts. Interestingly, DERBY and OAKS were identical trials, and even pooled analysis of their data showed stat sig. However, since they did the two trials, it is now uncertain whether the FDA will accept pooled analysis. Logic dictates that the FDA at least ask for an explanation of the difference in data; so far, the company hasn’t offered any.

In March this year, the company presented much more favorable 18-month data from both these phase 3 studies, DERBY and OAKS:

According to data at 18 months, from months 0-6 to months 12-18, the reduction in GA lesion growth improved with monthly pegcetacoplan to 21% from 13%. With every other-month pegcetacoplan treatment, the improvement reached 17% from 12% for the two periods.

While the improvements were marginal, they were able to push the outcome to one of statistical significance. Durability was also maintained over the 18 months. This data was part of the NDA; however, the company plans to present 24-month data in September, which won’t be; the FDA, however, may request that this data be included, which may cause some delay, as it may be considered a major amendment to the NDA.

Financials

APLS has a market cap of $5bn and a cash reserve of $965mn. R&D expenses were $90.9 million for the first quarter of 2022, while G&A expenses were $51mn. At that rate, they have a cash runway of 6-8 quarters.

The company made $15mn in net US revenue in 2021, while in Q1 2022, they made $12mn. Most of 2021’s revenue - $9mn - came in the fourth quarter, so it seems that sales are gradually picking up.

Bottomline

Given the high unmet need, relatively safe profile, and positive data from one trial, the drug definitely has more than a fair chance of approval. The company does have a solid cash reserve, and revenue may be picking up slowly. The stock is trading midway between its 52-week high and low. I would wait for a price below $35 to get in with a midterm window.

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College football season win totals moving at Circa Sports

College football season kicks off in two months, and regular-season win totals are on the board — and on the move — at sportsbooks.Circa Sports posted win totals on every Power Five conference team June 10, and there have been 11 line moves of a half-win or more based on sharp bets and the opinion of Circa sportsbook director Matt Metcalf.“Ninety percent of the money is sharps playing off some of the biggest differences at some of the other books,” Metcalf said. “In my experience, the more opiniona...

College football season kicks off in two months, and regular-season win totals are on the board — and on the move — at sportsbooks.

Circa Sports posted win totals on every Power Five conference team June 10, and there have been 11 line moves of a half-win or more based on sharp bets and the opinion of Circa sportsbook director Matt Metcalf.

“Ninety percent of the money is sharps playing off some of the biggest differences at some of the other books,” Metcalf said. “In my experience, the more opinionated sharp money doesn’t come in until a couple weeks before the season starts.

“Most of the half-win moves are me putting my opinion in looking for action. If I put up a number and nobody bets it, I see that as an opportunity to move it higher or lower.”

Alabama and Georgia are tied for the highest win total at 11½, and Ohio State is next at 11.

Metcalf recently lowered the Crimson Tide from the +195 favorite to win the national title to +165. The defending champion Bulldogs are +315 and the Buckeyes +350.

“I had Alabama two points better than Georgia and now have them four points better than Georgia. Ohio State is a point or two worse than Georgia,” he said. “It’s those three teams and everybody else.”

Georgia’s win total price opened at -110 before moving to under-145.

“Any time you open a team at 11 or 11½, you’re pretty much asking for wiseguy under money,” Metcalf said. “You’re basically asking a team to go undefeated, and that’s no easy task.”

Down on Cougars

Washington State is the only team that has moved a full win, dropping from 6 to 5 after sharp bettors pounded the under.

Cougars coach Nick Rolovich and four assistants were fired midway through last season for refusing to comply with a mandate that required all state employees to be vaccinated against COVID-19. The team still won three of its final four regular-season games.

“I was very impressed with how Washington State ended last season. They didn’t fall apart when the coach got fired,” Metcalf said. “But the more I thought about it, it’s going to be such a rebuild.

“We took money under 6 and took more under 5½. Six was a really bad opener. At six, you’re saying you’ve got to win seven to beat you. That’s asking a ton for that team.”

Falling totals

Six teams saw their totals dip by a half-win: Arizona (3½ to 3), Boston College (7 to 6½), California (6 to 5½), Illinois (5 to 4½), Indiana (5 to 4½) and Iowa State (7½ to 7).

“There’s a lot of teams I like and probably opened higher than the market,” Metcalf said. “I always like Cal. They never have enough offense, but they’re well-coached.

“I like Iowa State. They underachieved a lot last year. I know they lost a lot of offense, and people might not be as optimistic as I am. But I like the program, and I like (coach) Matt Campbell.”

Rising totals

Four teams saw their totals rise by a half-win: Michigan State (7 to 7½), North Carolina State (8 to 8½), Nebraska (7 to 7½) and Purdue (7 to 7½).

Metcalf said he has an anti-Michigan State bias that stems from his days as a professional bettor, when he was repeatedly burned by the Spartans when he faded them.

“They were never that great on paper but always overachieved,” he said. “If you ever want to bet on Michigan State over, it’s always good to come to Circa. I’ve tried to work the bias out, but it’s in my blood at this point.”

Metcalf said a lot of bettors are going to be on N.C. State, which went 9-3 last season and will return quarterback Devin Leary, who threw for a school-record 35 touchdowns.

“They’re like a solid C-, C+ program,” he said. “If they come out and play to a B+ level, they’re going to go over their win total.”

Nebraska went 3-9 last season, with all nine losses by less than 10 points.

“Nebraska last year played to a good power rating number,” Metcalf said. “But they had bad luck and lost a lot of close games.”

Purdue went 9-4 last season and is a 3-point home underdog to Penn State in their Sept. 1 season opener.

“I like the coach (Jeff Brohm), and I think Purdue could have a decent season,” Metcalf said. “The Week 1 Penn State line tells you the market likes Purdue.”

Contact reporter Todd Dewey at tdewey@reviewjournal.com. Follow @tdewey33 on Twitter.

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